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We reviewed the latest evidence available, which includes: 1 systematic review, 1 narrative review, 1 general review and 1 pilot study in humans

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Increased levels of kynurenine catabolites together with tryptophan depletion in the local microenvironment result in metabolic stress on CD4 T cells, leading to impaired T-cell metabolism, impaired antigen-specific response, cell cycle arrest and apoptosis of Th1 cells, inhibition of Th17 cell differentiation, and promotion of Th2 cell polarization [320, 323,324,325]

10.1074/jbc.M202919200 J

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