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The nasal spray format is particularly interesting for circadian research because evening administration timed to coincide with the natural onset of melatonin secretion delivers epitalon to the brain via nose-to-brain pathways at the moment when pineal melatonin production should be increasing
PMID: 38882173 Biochim Biophys Acta Mol Basis Dis Apigenin enhancing oxidative resistance and proteostasis to extend lifespan via PTEN-mediated AKT signalling pathway
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