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MAPK signaling contributes to therapeutic resistance by enhancing the expression of drug efflux transporters such as MDR1 and P-gp and by upregulating antiapoptotic genes such as Bcl-2

PHH that were exposed to NFT before displayed less damage evoked by stressors such as paraquat or rotenone and hence fully confirmed the observations made with the HepG2 model

This multi-target intracellular signalling profile accounts for its consistent positive results across tendon, ligament, muscle, bone, skin, and gastrointestinal tissue repair models in the published literature

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Once the kidneys fail, people with ADPKD require dialysis or a kidney transplant