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Persistent fatigue beyond 16 weeks, despite adequate nutrition and hydration, points to potential complications like thyroid disease, anemia, or vitamin B12 deficiency

503A compounding pharmacies will generally no longer be able to rely on the FDA shortage list exception for compounding essentially copies of tirzepatide products

Refer patients to structured education & weight management programmes Support patients to access structured education and weight management programmes where available

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Patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2) should not use this medication