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This cortisol-neutral profile is important because elevated cortisol is associated with increased appetite (particularly for high-calorie foods), abdominal fat accumulation, and metabolic complications

High-dose prescription EPA (icosapent ethyl) demonstrates robust evidence of MACE risk reduction in hypertriglyceridemic, high-risk populations, while mixed EPA + DHA supplements exhibit more variable efficacy

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The abdominal region is the preferred injection site, though thighs and upper arms are acceptable alternatives