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However, with the prevalence of skin permeation enhancement methods (such as microneedles and laser) used in cosmetic and pharmaceutical industry 15 , copper compounds may pose a higher risk to cause skin irritation, which necessitates a thorough skin toxicity testing
On a U-100 syringe, your 0.25mg dose falls at 12.5 units
CRC Press,Boca Raton, Florida
doi: 10.1111/j.1432-1033.1993.tb17986.x 32 DeaconCFJohnsenAHHolstJJ
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