soul trial oral semaglutide cardiovascular outcomes trial shows has positive CV benefits in type 2 diabetes SOUL Trial Shows Oral Semaglutide

usually improves over several weeks Diarrhoea or constipation : Altered bowel habits due to delayed gastric emptying Abdominal discomfort : Bloating, dyspepsia, or gastro-oesophageal reflux symptoms Practical management strategies recommended by NICE and specialist diabetes services include: Starting at the lowest licensed dose and titrating gradually according to the product's summary of product characteristics Eating smaller, more frequent meals and avoiding high-fat foods Maintaining adequate hydration, particularly if experiencing vomiting or diarrhoea Taking the injection at a consistent time as specified in the SmPC for your particular medication Less common but important adverse effects include: Injection site reactions : Rotate injection sites systematically between abdomen, thigh, and upper arm to minimise localised reactions Hypoglycaemia : Risk increases when GLP-1 agents are combined with insulin or sulphonylureas

Your weight naturally fluctuates from day to day depending on how much youve had to eat and drink, how active you were, and whether your body has retained any water

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Pathogenesis, clinical manifestations, and natural history of diabetic kidney disease

D., Goldstein, S