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Wegovy, like Saxenda, is a (GLP-1) receptor agonist

Traditional subcutaneous injection provides the highest bioavailability, typically 80-95% of the administered dose reaching systemic circulation

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Back GBD 2019 Risk Factor Collaborators (2020) 'Global Burden of 87 Risk Factors in 204 Countries and Territories, 19902019: a systematic analysis for the global burden of disease study 2019', The Lancet , 396, 122349

For other symptoms, its less clear that hormone therapy will help