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Each parent carries one copy of the mutated gene but often shows no signs or symptoms

Safety in a FIH trial is managed pro-actively it's built into the design from day one

Boxplot showing increased GPX4 protein expression in committed AML (n = 96 patients)

In chronic cholestasis, genetic testing is advised after excluding primary biliary cholangitis (PBC) through auto-antibody testing and primary sclerosing cholangitis (PSC) via MRCP, as well as in atypical autoimmune liver diseases such as AMA/ANA-negative PBC or small-duct PSC

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