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Ice crystal formation physically disrupts peptide structure

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IGF and proinsulin share homology such that both of their respective receptors, IGFR and the insulin receptor (IR), will bind to the alternate growth factors albeit with reduced affinity ( The vast majority of GH actions are mediated through the JAK-STAT signaling events which has multiple complex roles, such as regulating cell proliferation and oocyte maturation (Figure 1) (115, 116) and significant downstream crosstalk with the other pathways (117)