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For example, Muayad et al compared 61,998 patients with diabetes using GLP-1 RAs with metformin users in the US Collaborative Network of the TriNetX EHR database to calculate the risk of developing ocular hypertension or primary open-angle glaucoma, requiring topical glaucoma medication, or requiring laser trabeculoplasty

The gradual dose titration recommended in prescribing guidance aims to minimise gastrointestinal side effects by allowing the body time to adapt to the medication's effects on gut motility

The S1 hydrophobic pocket includes catalytic residues and is the primary determinant of substrate specificity