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The redox inactivation of SAL1 promotes the transport of PAP from chloroplasts (and mitochondria) via PAPST transporters to the nucleus where it inhibits exoribonuclease-mediated RNA metabolism (Figure 2 and Supplementary Table 3)
The receptor population recovers within 710 days of peptide cessation, which is why cycling protocols (5 days on, 2 days off, or 3 weeks on, 1 week off) prevent tolerance buildup
This interaction may result in activation of adenylate cyclase (AC), an enzyme catalyzing the conversion of ATP into cyclic adenosine monophosphate (cAMP)
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