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Type 2 diabetes with severe insulin resistance sometimes requires additional insulin-sensitizing interventions alongside GLP-1, or a medication like tirzepatide that works on dual pathways (GLP-1 and GIP receptors) for superior metabolic impact

AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway

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