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Vitamin B 12 metabolism and massive dose methyl vitamin B 12 therapy in Japanese patients with multiple sclerosis

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Despite elevated intracellular GSH levels and increased redox cycling activity, the transcriptomic data indicated downregulation of Gss (glutathione synthetase), Gclc (glutamate cysteine ligase catalytic), and Chac1 (a canonical GSH-degrading enzyme), alongside significant upregulation of Chac2, a less characterized homolog involved in glutathione regulation (Fig

doi: 10.1093/ndt/gfv095 159 VoroneanuL.BurlacuA.BrinzaC.CovicA.BalanG