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Edited MRS (i.e

Use in Special Populations 12

However, as weight decreases, the rate of loss may slow, which is a normal biological response rather than reduced effectiveness of the medication

Several mechanisms that can explain this association are increased sodium and water retention due to the renin-angiotensin-aldosterone pathway overactivation, peripheral vasoconstriction attributed to endothelial dysfunction, and low nitric oxide production [17]