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Structural analyses show that cagrilintide mimics amylins receptor engagement while introducing conformational differences at select positions, such as Pro37, which enhances CTR interaction and modulates receptor dynamics (Cao et al

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D., Brighenti, F., & Porrini, M

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Ann Thorac Surg 111: 1095-1097, 2021

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They play an important role in brain-peripheral communication in physiology and pathophysiology

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