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Whats the evidence for this mechanism
Nevertheless, many of the large-scale cardiovascular trials have reported the effects of DPP-4 inhibitors on aspects of diabetic nephropathy, specifically changes in urinary protein excretion, in glomerular function over time, and in the risk of progression to end-stage renal disease [47, 48, 84]
One of the main autoimmune disorders associated with this therapy is the development of autoimmune hypophysitis and isolated adrenocorticotropic hormone (ACTH) deficiency (67)
Tasaki S, Suzuki K, Kassai Y, et al
KPV is the tripeptide Lys-Pro-Val, 342.4 g/mol, the C-terminal fragment of alpha-melanocyte-stimulating hormone corresponding to residues 11 to 13
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