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10.2337/diabetes.50.3.609 191 WaughN.CumminsE.RoyleP.ClarC.MarienM.RichterB.et al (2010)
However, compared with the in vivo model, the in vitro model is irreplaceable in the study of organ-level distribution quantification (the in vivo model can accurately capture the distribution of drugs in inert tissues such as the brain, fat and bone through real-time monitoring in vivo , such as PETCT imaging and organ biopsy)
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The pathophysiology is unclear, but risk factors are thought to be the same as the type 1 diabetic patients who rapidly improved A1c in the Diabetes Control and Complications Trial: long duration of diabetes mellitus, long duration of poor glycemic control, worse baseline level of DR prior to treatment and magnitude of reduction in A1c after treatment
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