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In this study, we found by mRNA sequencing that a variety of genes involved in cell cycle regulation, DNA replication and mitosis were significantly up-regulated in RRM2 overexpressing cells ( RRM2 -OE-TPC-1) in the experimental group, as shown in the Supplementary Table 4

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GHK-Cu appears to reset this decline by upregulating the transcription factors that drive fibroblast proliferation