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Hyperglycemia activates the polyol pathway, increasing sorbitol and fructose production, which induces osmotic and oxidative stress in muscle cells
The peptide induces cell death through suppression of survivin expression, a protein that inhibits apoptosis in cancer cells
The goal is to increase knowledge on the key adipogenesis determinants function and relevance to adipose tissue pathophysiology, resulting in new targets for anti-obesity drug development without compromising patients health
[35] Etminan M, Takkouche B, Caamano-Isorna F
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