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LCACs also affect Ca 2+ homeostasis between the mitochondria and the ER

There have been two case reports in which prothrombin time (INR) increased in patients who started taking garlic tablets or garlic oil without changing their warfarin dose or other habits (155)

The other famous one is dinitrophenol (DNP), which has an incredibly narrow dose window people took it and saw big weight loss, so took more of it and dropped dead leading it to be the first drug ever banned by the then newly formed FDA

These can usually be resolved by lowering the dose or dividing it into smaller, more frequent administrations

Tirzepatide represents a significant advancement in the treatment of type 2 diabetes and obesity