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Regarding the role of GS in immune cells, as discussed above, it can be dichotomous, since glutamine can promote or hamper, depending on the cells and context, antitumor immunity [166, 172, 182, 192,193,194] (Table 8)

There are two apoptotic pathways: the extrinsic pathway, which is activated by death receptors, and the intrinsic pathway, which can be activated by hypoxia and oxidative stress that occur due to cardiopulmonary bypass [8, 9]

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Nature 567:118122 Kraft VAN, Bezjian CT, Pfeiffer S, Ringelstetter L, Mller C, Zandkarimi F et al (2020) GTP cyclohydrolase 1/Tetrahydrobiopterin counteract ferroptosis through lipid remodeling