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can temporarily reduce immune competence or even disrupt the regulation of systemic inflammation (61)
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In this sense, the two approaches are not necessarily competing
Upon antigen encounter, successful activation triggers a metabolic shift: Effector T cells upregulate aerobic glycolysis (the Warburg effect) to rapidly generate biosynthetic precursors (nucleotides, amino acids, lipids) necessary for clonal expansion and cytokine production, while still maintaining OXPHOS capacity
It remains a subject of ongoing scientific evaluation in controlled research environments
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