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The knowledge of the complex interplay between genetic, environmental, and microenvironmental factors is critical for developing better diagnostic and therapeutic approaches
They found that MYC amplification promotes transcription of the E3 ligase KLHL42, leading to pRB1 ubiquitination and degradation, thereby conferring resistance to CDK4/6 inhibitors
Anita Petruzzelli, a dual board-certified OB-GYN and integrative medicine physician, combines advanced medical science with personalized, patient-focused strategies to deliver comprehensive care
Instead, it adheres to the outer mitochondrial membrane and possesses an N-terminal myristylation motif
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