Other groups who may benefit include: Patients following gastric surgery (gastrectomy, bariatric procedures) where intrinsic factor production or absorption sites are compromised Individuals with malabsorption disorders such as Crohn's disease, coeliac disease, or chronic pancreatitis Strict vegans and vegetarians with dietary insufficiency, though oral supplementation is usually tried first Elderly patients with atrophic gastritis or reduced gastric acid production Patients on long-term metformin or proton pump inhibitors, which can impair B12 absorption [6] [8] Individuals with nitrous oxide exposure (recreational or medical), which can cause functional B12 deficiency Diagnosis typically involves serum B12 measurement, with levels below approximately 148 pmol/L (though thresholds vary between laboratories) generally indicating deficiency
Serious reactions are uncommon but include hypersensitivity and anaphylaxis, more often reported with parenteral thiamine
Working with this compound
This article examines the compatibility, benefits, and safety considerations when combining B12 injections with Mounjaro therapy
Restoring NAD+ levels is one of the most promising areas of longevity research, particularly when combined with complementary metabolic compounds
