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Acute symptoms such as fatigue may improve within days, whilst neurological symptoms like paraesthesia typically require weeks to months of treatment

This places the compound within a broader research context involving NAD+ biology, sirtuin signaling, and methylation-dependent gene regulation

In addition, there has not been any reports of adverse effects associated with the intake of normal daily requirements of vitamin B12 during lactation

It is also worth being explicit about what documented means here, because it is the load-bearing word for a YMYL page

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