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its activation is therefore described throughout this review as contributing to or being associated with downstream metabolic consequences, rather than as a sole causal determinant

Side effects are one contributing factor with respect to discontinuation

Sleep disorders like restless legs syndrome, periodic limb movement disorder, and circadian rhythm disorders can coexist with tirzepatide treatment and require separate diagnosis and management

Tirzepatide produced dramatic weight loss, roughly 20% of which was LBM, which is close to the quarter FFM formula

A caveat of using these medications is that many have reduced renal clearance due to declining kidney function or are contraindicated and often require careful dose adjustments [11,12,13]