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Contrary to CHAOS, the HOPE trial failed (Yusuf et al
AOD9604 and Energy Balance Research In obese ob/ob and lean C57BL/6J mice treated for 14 days via mini-osmotic pumps, AOD9604 significantly reduced body weight gain in obese mice, associated with increased in vivo fat oxidation and increased plasma glycerol levels as an index of enhanced lipolysis without the hyperglycaemia or reduced insulin secretion associated with intact hGH treatment
10.1126/science.1098014 Science 23 ArunS.LiuL.DonmezG
(PubMed) Lei YP, Liu CT, Sheen LY, Chen HW, Lii CK
doi:10.1093/brain/awq269
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