In 5xFAD mice, early-life stress such as maternal separation results in enhanced A deposition in the anterior cingulate cortex and basolateral amygdala (Garcia et al., 2023)
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Participants who received semaglutide had a 24% risk reduction for the composite primary endpoint, including kidney outcomes and death due to cardiovascular and kidney causes, compared to those who received placebo
Both acute GLP-1 infusion (65, 66) and a single liraglutide dose (67) decreased plasma ANG II concentration in healthy subjects and type 2 diabetic patients, consistently with an inhibitory effect of GLP-1 on renin secretion (68, 69)
Hurtado I, Robles C, Peir S, Garca-Sempere A, Sanflix-Gimeno G