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Calcium overload triggers the activation of calcium-dependent enzymes, including calpains and caspases, which degrade cytoskeletal proteins and lead to neuronal death (Zhang and Bhavnani, 2006)

The version that has lost its patent is Victoza, which is approved for diabetes and packaged as an injection pen that is prefilled with the antidiabetic doses (0.6, 1.2, and 1.8 mg), which are lower than the typical antiobesity doses

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Patients taking these combinations may require dose adjustments of their diabetes medications

However, unlike glycolytic and lipogenic pathways, where specific metabolic enzymes such as hexokinase 2 and FAS are known to be deregulated by oncogene(s) or by inactivation of tumor suppressors 16,17 , there is limited evidence for cancer-associated abnormal expression or activity of the enzymes directly involved in the FAO pathway