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This is also consistent with the fact that mPGES-1s also catalyze the GSH-dependent PGH 2 isomerization into PGE 2 with good efficiencies (Thoren et al., 2003)
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In the case that one has at least one medical condition resulting from obesity, like hypertension, diabetes, sleep apnea, etc., this drug could be used starting at a BMI of 27, which would be equivalent to a lower weight compared to healthier individuals
