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Groups with limited or no safety data Published human trials with AOD-9604 enrolled adults with obesity (BMI 30-45 kg/m^2), generally aged 18-65

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From there the voluntary muscle activity was recorded from the most caudal pair of electrodes, followed by measurement and recording of the average motor unit potential (UMP) and the compound motor action potential (CMAP)

It also means that the dose-response curve is steeper, which reinforces why accurate calculation and gradual escalation are non-negotiable