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The dose-response relationship is not linear

Hollister Murray and W

Clinical trials consistently show that patients on semaglutide experience improved insulin sensitivity within 812 weeks, even before significant weight loss occurs, indicating that metabolic healing precedes and enables lasting fat reduction

In published phase 2 studies, participants received subcutaneous injections at fixed weekly intervals with predefined dose levels and gradual up titration schedules rather than ad-hoc adjustments