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[1] Treatment with the anticonvulsants valproic acid, phenobarbital, phenytoin, or carbamazepine significantly reduces blood levels of carnitine

The result is weight gain, metabolic dysfunction, and chronic fatigue

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The cryo-EM structures of retatrutide-bound GLP-1R, GIPR and GCGR reveal a combination of conserved peptidereceptor interactions and receptor-specific conformations, particularly in ECL1, that enables retatrutide to execute agonism at multiple receptors

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