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The secondary endpoints included changes in body weight and fasting plasma glucose

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Body weight is the most obvious: weight-based protocols scale the dose to body mass, so a heavier individual using a per-kilogram protocol would use proportionally more

A total of 40 participants were selected and randomized into two sequences in a double-blind, placebo-controlled crossover design, with a one-week washout period between treatments to eliminate carryover effects

Open-label, single center, dose finding phase I-study with Atu027 (an SiRNA Formulation) in subjects with advanced solid Cancer