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-Cell is vulnerable to reactive oxygen species (ROS) 7,8

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Pharmacodynamic effects of anti-IL-23p19 inhibition are longer than pharmacokinetic effects, thus the impact on psoriasis can continue many months after the drug is excreted

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Conclusively, these findings revealed that ECSCs might enhance stemness properties, spontaneously differentiating towards the epithelium in long-term culture and to develop the ECSC phenotype and pluripotency