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This has timing implications

Long-Term activation of Glucagon-like peptide-1 receptor by dulaglutide prevents diabetic heart failure and metabolic remodeling in type 2 diabetes

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56 These trials demonstrate that although orforglipron is safe and efficacious more longitudinal research is warranted to provide deeper insights into their efficacy, safety and tolerability before their potential incorporation in the pharmacological arsenal against T2DM or obesity

Anna-Kay Palmer from Jefferson Einstein Hospital in Philadelphia provided further evidence