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Do not use if the seal is broken

Immunomodulators such as azathioprine, 6-mercaptopurine, and methotrexate serve as steroid-sparing agents and are often used in combination with biologics

Step 2: Lab Work (When Needed) Not all providers ask for lab testing before prescribing semaglutide, but the more thorough ones usually do

All options should be discussed with the patient

A larger follow-up RCT (n=72 older adults) confirmed these findings, additionally demonstrating improvements in gait speed (+0.14 m/s), grip strength, 6-minute walk distance, waist circumference reduction, and systolic blood pressure reduction (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]