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Conversely, if a patient presents with pernicious anemia or severe neurological signssuch as intense tingling in the hands, memory loss, or muscle weaknessthe dosage remains the same (usually 1,000 mcg), but the frequency increases significantly

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doi: 10.1016/j.jtcvs.2013.12.048 171 WeberBLacknerIGebhardFMiclauTKalbitzM

This suggests that while individual smaller studies may fail to detect the link, the cumulative evidence supports an association

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