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Liraglutide and dulaglutide generally show better tolerability but still require careful counseling to maintain adherence ( Overall, the comparative evidence suggests that long-acting and multi-agonist agents maximize efficacy at the expense of higher gastrointestinal intolerance, whereas older agents provide more modest benefits with relatively favorable tolerability

Pregnant and breastfeeding women, people with known allergies to glutathione, and those taking specific medications may also need to avoid treatment

This hypothesis is what led to the launch of this clinical trial, in which no benefit has been demonstrated

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The studies are correlative, but appear to show that the drugs not only reverse the carcinogenic risks that come with obesity, they may also have additional anti-inflammatory effects that help suppress tumors