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For patients on tirzepatide, which produces a more pronounced caloric deficit due to its dual GIP/GLP-1 mechanism, methylated B12 provides upgraded energy and cognitive support during the weight loss phase

This demonstrates a cognitive regulation of satiation, in which a feed-forward mechanism increases satiation before the initiation of a meal, eventually leading to meal termination (Fig

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Upon promoting better glycaemic control and reducing hyperinsulinemia, the yogic diet may directly and indirectly contribute to the reduction in inflammatory pathways associated with insulin resistance (Fig