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This reduced response is driven by insulin resistance, diabetic medications (some of which promote weight gain), and metabolic dysfunction that blunts the full effect of GLP-1 therapy

Patients meet with medical professionals who review health history, evaluate goals, and determine if semaglutide is an appropriate option

Cleveland Clinic 2025 Assessed and Endorsed by the MedReport Medical Review Board

Practical implementation: set intake targets based on training load rather than hunger, and prioritize easily digestible carbohydrate sources (white rice, potatoes, sports drinks, fruit) that clear the stomach faster despite delayed gastric emptying

Establish a hydration baseline