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44 The principles of the Redox Code were raised in 2015, 45 including the regulation of NADH and NADPH systems in metabolism, dynamic control of thiol switches in the redox proteome, activation and deactivation cycles of H 2 O 2 production, and the response of redox signaling to environmental changes at various cellular levels, paved the way for new insights into disease-specific therapeutic targets through advanced biotechnological exploration of redox proteomics