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For context, the concentrations required to activate intracellular cascades such as PI3K/Akt, upregulate BDNF, or stimulate autophagy in neuronal tissue are derived from preclinical studies that used substantially higher relative exposures than those achievable in the human brain at therapeutic doses

b , Left, size-exclusion chromatography profiles showing UV absorbance at 280 nm for purified SLC33A1 MAP

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