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Combined Approaches (Neelakantan et al., 2022): NNMT inhibition with reduced-calorie diet produced dramatic adiposity reduction in DIO mice, normalizing metabolic parameters and establishing a distinct gut microbiome
Discomfort is minimal and resolves within seconds
A concentration-response design, vehicle-matched control, target-engagement marker, and parallel genetic or pharmacological validation can strengthen attribution to NNMT biology
### The Fragment AOD-9604 is a modified form of amino acids 176-191 of the Growth Hormone polypeptide
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