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10.1056/NEJM199807233390404

One of the key pathways through which MOTS-c exerts its effects is by activating AMP-activated protein kinase (AMPK) signaling

The table lists mild to moderate nausea in 40-50% of people as the expected gastrointestinal adjustment, and attributes the variation to gastric emptying rate, GIP receptor pathway sensitivity, and prior gastrointestinal tolerance