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Do not remove the outer or inner needle caps yet
Baseline: Metformin 1000-2000mg daily, stable dose Weeks 1-4: Add Retatrutide 1mg weekly, maintain Metformin Weeks 5-8: Increase Retatrutide to 4mg weekly Weeks 9-12: Increase Retatrutide to 8mg weekly Week 12+: Assess A1C and consider Retatrutide dose increase to 12mg if needed
A still unsolved issue, connected with the role of carnitine in modulating gene expression (Figure 1) is the link between mitochondria and nucleus: acetylcarnitine produced in mitochondria would reach the nucleus providing acetyl units (Figure 2)
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