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Anti-obesity and glucose-lowering pharmacotherapies predominantly exert their actions by inducing satiety (liraglutide, setmelanotide, lorcaserin, pramlintide, sibutramine) or by inducing malabsorption of nutrients (orlistat)
8 SUMMIT also demonstrated significant improvements in patient-reported outcomes: at 52 weeks, tirzepatide increased KCCQ-CSS, with a between-group mean difference of 6.9 points, and increased 6-minute walk distance, with a between-group mean difference of 18.3 m
Large cardiovascular outcome trials have provided the most robust safety data available
Furthermore, recent studies show the benefits of tirzepatide in people with metabolic dysfunctionassociated steatohepatitis (MASH) [5], in people with heart failure with preserved ejection fraction (HFpEF) and obesity [6], and in people with T2D with established atherosclerotic cardiovascular disease according to a recent press release [7]
Studies show that these strains may help reduce body weight, body fat mass, and waist circumference
