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Taguchi, A., Wartschow, L
In the SURPASS-2 trial, patients treated with Mounjaro 15mg achieved approximately 21% body weight reduction (average of 12.4 kg or 27 lbs), compared to Jardiances more modest 3-5% weight loss (3-4 kg) that typically plateaus around month 6
Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria
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For example, in humans our fasting normal concentration of total GLP-1 is typically 510 pmol/L and can increase up to ~40 pmol/L in response to a meal
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