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A first dose-escalating clinical safety trial in 17 volunteers using male Sm cercariae, which do not produce eggs and therefore do not cause lasting pathology, as a challenge was recently conducted in Leiden, the Netherlands (NCT02755324)
Lower concentrations are easier to dose accurately but require larger injection volumes per administration
Harms, A., Maisonneuve, E
doi:10.1073/pnas.2018138117 CrossRef Wang Q, Huang Y, Qin C, et al
(PubMed) Silberstein SD, Holland S, Freitag F, et al
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